Isabelle Duthoit trained as a classical clarinetist and has always been interested in the voice. She has developed a singular vocal technique, seeking "a language before language, a voice of origin". She has collaborated with Georges Aperghis, Gilbert Amy, Daniel d'Adamo and Klaus Huber, then turned to free improvisation, working with many artists of the international experimental scene such as
Phil Minton,
Dieb13 or Angelica Castello. She is a member of several groups such as Hiatus, Système Friche, Where is the sun, Uruk, Iki, NYX. She regularly performs in dance and theater.